Author/year	Design	Setting	Population/ sample	Intervention(s) or Goal	Outcome	Results	Strengths/ Weaknesses	Implications
Marcantonio et al., 2022[@192886]	Prospective diagnostic test study	2 hospitals in NE U.S.	527 patients and 399 clinicians	Establish diagnostic accuracy of smart tablet-based delirium assessment protocol	Accuracy of assessment protocol compared to research standard delirium assessment	UB-2 Accuracy: 69% CNA’s, 73% nurses, 70% physicians 2-step protocol accuracy: 89% nurses, 87% physicians	Large sample, clinicians blinded to standard assessment results Few assessments per provider, limited provider training	Smart tablet app-based delirium identification protocol was feasible, quick, and accurate.
Van Sleuwan et al., 2021[@192887]	Retrospective, single centre, observational cohort study	Single, academic hospital in NE U.S.	373 adults undergoing EEG to evaluate altered mental status	Development of EEG tool to quantify delirium severity	Correlation of E-CAM (EEG tool) with CAM-S	E-CAM-S scores correlate with clinical CAM-S scores (r=0.68; p < 0.001)	Automated EEG approach Heterogeneous sample, single centre, CAM-S performed by multiple providers	E-CAM-S is a promising automated tool for physiologically based monitoring of delirium severity
Yang et al., 2021[@192888]	Human cell and mouse study	Academic centre in U.S.	Inbred C57B/L6J and Cx3cr1GFP mice (males and females; 12-16 weeks old)	Determine effects of omega-3 fatty acids on neuroimmune interactions after orthopaedic surgery	Multiple, including measure of delirium like behavior in mice and development of BBB-on-chip platform	Omega-3 fatty acids reduced delirium-like behavior and blood-brain-barrier impairment	Novel, new BBB-on chip platform Focused on IL-1\(\beta\) as while the immune response in delirium is complex. Preclinical nature limits clinical applications currently	BBB-on-chip device with primary human cells can be used to characterise neuroimmune interactions Omega-3 fatty acids may protect the BBB from surgery-induced neuroinflammation and protect against surgery-induced attention deficits